Sulphonamides in Urine
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The rapid detection of metronidazole in urine.
When metronidazole (Flagyl) is prescribed for trichomoniasis or lambliasis, it is unusual for the treatment not to be followed-up; however, it is possible that the patient does not take the drug, and the doctor may wonder whether the drug is being properly absorbed. It is also thought that metronidazole decreases the desire for alcohol in alcoholics. Here the co-operation of the patient may be ...
متن کاملThe metabolism of four sulphonamides in cows.
1. The metabolism of sulphanilamide, sulphadimidine (4,6-dimethyl-2-sulphanilamidopyrimidine), sulphamethoxazole (5-methyl-3-sulphanilamidoisoxazole) and sulphadoxine (5,6-dimethoxy-4-sulphanilamidopyrimidine) given by intravenous injection has been examined in cows. 2. The sulphonamides were present mainly as unchanged drugs in blood samples collected 2h after administration. 3. The sulphonami...
متن کاملChoice of sulphonamides for mixture therapy.
Extensive experimental and clinical studies of the last five years have established the advantages of sulphonamide mixture therapy. 1-17 In brief the rationale for the use of mixtures is as follows: The renal toxicity of most of the newer sulphonamides, if used singly, is due primarily to over-saturation of the tubular urine with a sparingly soluble sulphonamide and/or its metabolic product, re...
متن کاملA novel rhodium-catalyzed domino-hydroformylation-reaction for the synthesis of sulphonamides.
An efficient and highly selective method for the synthesis of sulphonamides by a domino hydroformylation-reductive sulphonamidation reaction has been developed. Various olefins and sulphonamides are converted into the desired products in good yields and with excellent selectivities in the presence of a rhodium/Naphos catalyst.
متن کاملSensitivity of Nocardia to trimethoprim and sulphonamides in vitro.
Studies in vitro of the sensitivity to trimethoprim and sulphonamides of nine strains of N. asteroides, two strains of N. caviae, and one of N. blackwellii are presented. No unequivocal evidence of synergism was found. Despite this, the inclusion of trimethoprim in the drug regime when sulphonamides are used in the treatment of nocardiosis is suggested on empirical grounds.
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عنوان ژورنال:
دوره 80 شماره
صفحات -
تاریخ انتشار 1945